Endocrine Abstracts

Background: Incretin-based therapy is increasingly used in the management of type 2 diabetes mellitus. Although dipeptidyl peptidase-4 inhibitors (gliptins) are well tolerated, side effects can be observed in various body systems. Here we report three cases of drug-induced skin eruption with strong itching of the gliptins plus metformin combination therapy.Case reports: A 59-year-old woman and a 57-year-old man, who had been using vildagliptin plus metfo...

Aim: To evaluate prevalence of erectile dysfunction (ED) in patients with type 2 diabetes in relation to the cardiovascular risk factors.Methods: A total of 116 males including type 2 diabetic patients (n=68, mean age: 56.7 (5.8) years) and age-matched healthy controls (n=48, mean age: 57.0 (6.6) years) were included to study. Concomitant hypertension, hyperlipidemia, and coronary artery disease (CAD) were recorded in each subject along...

Aim: Erectile dysfunction (ED) has been reported to occur more commonly in diabetes than general population with the prevalence rate varies widely from 35 to 75%. Patients with diabetes was also shown to have much earlier onset of ED and more severe form of the disease associated with a poorer quality of life. We aimed to evaluate association of ED with diabetes related complications in patients with type 2 diabetes in our study.Methods: In a total of 68...

Multiple myeloma is a neoplastic disorder arising from plasma cells in the bone marrow. Plasma cell tumors, plasmacytomas, are uncommon in the brain and occur usually in the leptomeninges with or without parencymal involvement. Extramedullary plasmacytomas are very rarely located in the sella and can be misdiagnosed as a nonfunctioning pituitary adenoma. We report an illustrative case with multiple myeloma who was diagnosed having sellar plasmacytoma resembling a nonfunctionin...

Sex reversal syndrome (SRS) is a kind of human genetic disease about gender dysplasia, which is characterised by inconsistency between gonadal sexuality and chromosome sexuality. The clinical types include 46, XY female SRS and 46, XX male SRS. The early studies of human gonadal differentiation found that human Y chromosome contains testis-determining factor (TDF) found that the sex-determining region Y (SRY) gene, which is located in Y chromosome, was the best candidate gene ...

Hyperinsulinemia that occurs due to insulin resistance play an important role on the development of type 2 diabetes and hypertension. It is shown that apart from their angiotensin II receptor blockage effect, telmisartan and irbesartan can activate intracellular hormone receptor PPARγ. Owing to this dual effect, telmisartan and irbesartan can improve cardiovascular risk factors related to insulin resistance. The aim of this study was to compare the effects of telmisartan ...

Aim: To evaluate the relationship between glycemic control and quality of life parameters in patients with poorly controlled type 2 diabetes.Methods: Fifty patients with poorly controlled (HbA1c 8–12%) type 2 diabetes included the study and were answered DQOL and SF-36 questionnaires to an assistant in internal medicine. HbA1c levels, age, gender, duration of diabetes, height, weight and waist–hip ratio measurements recorded at the same time.</...

Thyroidectomy is an alternative treatment in the therapy of hyperthyroidism in patients who are non-compliant, drug-resistant or have various side effects to the antithyroid drugs. Preoperative preparation of hyperthyroid patients is extremely important to avoid per operative complications due to severe thyrotoxicosis. We investigated the effects of lugol solution usage with or without thionamides in the rapid preparation of thyroid surgery retrospectively. Twenty-two patients...

Objective: To determine the correlates of visceral and subcutaneous fat thickness in non-diabetic obese and morbidly obese patients.Methods: A total of 31 obese female outpatients composed of morbidly obese (n=16, BMI of ≧40 kg/m2) and obese (n=15, BMI of 30–39.9 kg/m2) patients were included in the present study. Data on age, anthropometrics, blood biochemistry, HOMA–IR, carotid intima-media thick...

Aim: To compare the effectiveness of insulin detemir when added to oral antidiabetic drug therapy as a single daily dose or twice daily.Method: Fifty patients with a diagnosis of type 2 diabetes receiving oral antidiabetic drug therapy and glycemic control did not provided were included the study. Insulin detemir was begun 0.1–0.2 U/kg daily dose, half of the patients started with a single daily dose and the other half with same dose twice daily. At...